When nicotine binds to receptors in the peripheral nervous system, it increases blood pressure, heart rate, cardiac contractility, and gastrointestinal tract activity.
IgA is the main antibody found in breast milk, tears, saliva, and the mucosal secretions of respiratory tract, gastrointestinal tract, and the genitourinary tract.
Alternatively, phosphate levels can rapidly increase in the blood from excessive intake and absorption through the gastrointestinal tract or bloodstream via intravenous fluids.